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kb2145  (Krishgen Biosystems)


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    Krishgen Biosystems kb2145
    Kb2145, supplied by Krishgen Biosystems, used in various techniques. Bioz Stars score: 94/100, based on 90 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kb2145/10__1186_slash_s41936___026___00580___8-77-35-46?v=Krishgen+Biosystems
    Average 94 stars, based on 90 article reviews
    kb2145 - by Bioz Stars, 2026-08
    94/100 stars

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    In vivo validation of allium PDNV-mediated suppression of psoriatic inflammation via NRF2-IL-17 axis (A–C) (A) qRT-PCR validation of selected genes in IMQ and PDNV-treated murine skin samples. Relative IL-17A, TNF-α, and IL-23 protein abundance in mice skin (B) or serum (C) quantified by ELISA ( n = 6). (D) Relative transcript abundance of NRF2 targets, HMOX1 , and NQO1 in IMQ and PDNV-treated murine skin samples. n = 6; error bar denotes mean ± SD. One-way ANOVA with Turkey’s multiple comparison test was used for post hoc analysis. (ns, non-significant, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). (E) Dorsal skin sections from mice were stained with antibodies against NRF2 (green) by immunohistochemistry and counterstained with DAPI (in blue). Scale bar,100 μm.

    Journal: iScience

    Article Title: Natural plant-derived nanovesicles for effective psoriasis therapy via dual modulation of IL-17 and NRF2 pathway

    doi: 10.1016/j.isci.2025.112556

    Figure Lengend Snippet: In vivo validation of allium PDNV-mediated suppression of psoriatic inflammation via NRF2-IL-17 axis (A–C) (A) qRT-PCR validation of selected genes in IMQ and PDNV-treated murine skin samples. Relative IL-17A, TNF-α, and IL-23 protein abundance in mice skin (B) or serum (C) quantified by ELISA ( n = 6). (D) Relative transcript abundance of NRF2 targets, HMOX1 , and NQO1 in IMQ and PDNV-treated murine skin samples. n = 6; error bar denotes mean ± SD. One-way ANOVA with Turkey’s multiple comparison test was used for post hoc analysis. (ns, non-significant, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). (E) Dorsal skin sections from mice were stained with antibodies against NRF2 (green) by immunohistochemistry and counterstained with DAPI (in blue). Scale bar,100 μm.

    Article Snippet: TNF-α ELISA kit , Krishgen , Cat#KB2145.

    Techniques: In Vivo, Biomarker Discovery, Quantitative RT-PCR, Quantitative Proteomics, Enzyme-linked Immunosorbent Assay, Comparison, Staining, Immunohistochemistry